SYMPLICITY HTN 3: The death knell for renal denervation in hypertension?
نویسندگان
چکیده
Resistant hypertension is, by definition, a challenge to most physicians treating hypertension. Renal sympathetic denervation has shown promising early results in treating this condition. The SYMPLICITY HTN-3 is the most recent trial to report the effects of this technique on resistant hypertension. This review discusses this study and its surprising neutral results before ending with an overview of key lessons learned.
منابع مشابه
Renal denervation for resistant hypertension?
Ever since Schlaich et al.1 first reported on a patient with a blood pressure of 161/107 mm Hg (despite treatment with seven different antihypertensive drugs) that decreased to 127/81 mm Hg after renal denervation, the medical community has been enamored with this procedure. Resistant hypertension evolved into a fashionable diagnosis, and the number of publications pertaining to it grew rapidly...
متن کاملEffect of Catheter-Based Renal Denervation on Morning and Nocturnal Blood Pressure: Insights From SYMPLICITY HTN-3 and SYMPLICITY HTN-Japan.
UNLABELLED High nighttime and early morning blood pressure (BP) have been associated with greater risk for cardiovascular events than high clinic or daytime BP. BP is typically highest in the rising hours, when morning activities typically begin. We examined the effect of renal denervation on morning (6:00-8:59 AM), daytime (9:00 AM-8:59 PM), and nighttime (1:00-5:59 AM) ambulatory BP. Patient ...
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The results of the Symplicity HTN-3 trial have been presented a few days ago in the 2014 Scientific Meeting of the American College of Cardiology and simultaneously published in the New England Journal of Medicine [1]. The Symplicity HTN-3 trial was the first placebo-controlled (via sham procedure) study evaluating the effects of renal sympathetic denervation (RSD) in patients with resistant hy...
متن کاملRenal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis
OBJECTIVE The objective of this study is to evaluate the efficacy and safety of renal denervation in patients with resistant hypertension. METHODS We searched MEDLINE and EMBASE for studies that evaluated the use of catheter-based renal sympathetic denervation compared to a control group and reported blood pressure results at follow-up. Data was extracted from relevant studies and pooled esti...
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ورودعنوان ژورنال:
دوره 2014 شماره
صفحات -
تاریخ انتشار 2014